Parkinson’s Disease

Worldwide, some 7-10 million people live with Parkinson’s disease (PD). In Luxembourg, it is estimated that about 1,200 people are affected by this chronic and progressive neurodegenerative disease.

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The risk of developing a neurodegenerative disease, such as Alzheimer’s or Parkinson’s disease, increases as we grow older, with up to 10% of PD patients already diagnosed before they turn 50. At the time of diagnosis, PD patients typically exhibit motor symptoms including muscle stiffness, shaking and slowness in initiating movement. PD takes years to develop and the damage to nerve cells is already extensive by the time these motor symptoms appear. However, up to 10-20 years before this, most patients will exhibit problems with their vision, constipation, sleep disorders, or a reduction in their sense of smell. These symptoms are today considered pre-motor risk factors for developing PD.

In order to treat patients as early and as efficiently as possible, it is imperative that accurate early diagnostic tests and better treatments be found. Understanding this urgency, the biobank participates in both, national and international, PD studies. At the same time, we work closely with the local patient association, Parkinson Luxembourg, to keep patients informed about PD research and show our solidarity.

International collaboration

PrintSince 2013, we have worked as the central European biobank for a project funded by the EU Joint Programme for Neurodegenerative Disease Research (JPND), the largest global research initiative aimed at tackling the challenge of neurodegenerative diseases. blood-collectThe cerebrospinal fluid and blood samples collected at multiple European hospitals are stored at IBBL and made available to scientists from 19 different countries. Besides taking care of the physical storage of biological samples for the project, we have set up a web-based IT platform that captures all data related to the samples and we have also participated in the research itself by assessing the way in which cerebrospinal fluid is processed in the laboratory.

In 2016, IBBL joined another JPND project as external collaborator. Researchers from Luxembourg, Germany, Austria, the Netherlands and Israel have been combining their strengths to culture human brain-like structures from Parkinson’s patient cells to elucidate the effects of the disease on the brain. Within the consortium, we are responsible for the reception of the samples, as well as for the expansion, storage and redistribution of the cells. In addition, our researchers help test a novel cryopreservation method for the brain structures.

Local excellence

The biggest initiative in PD research in Luxembourg was launched in 2015: the National Centre of Excellence in Research on Parkinson’s Disease (NCER-PD). Created by the Fonds National de la Recherche (FNR), NCER-PD is an 8-year programme that aims to find new ways for an earlier diagnosis and better treatment for Parkinson’s disease.

Over 600 patients and healthy donors from Luxembourg and the Greater Region participated in the study in 2018. This number reflects the strong interest and will of the Luxembourgish population to advance biomedical research. Their biological samples, such as blood, urine and saliva, were handled with the greatest care by the biobank, which also set up quality control tests to maximise donors’ contribution and ultimately ensure robust research outcomes.

Our national projects 

IBBL is involved in a number of national research projects on Parkinson’s disease and neurodegeneration, in close collaboration with all major biomedical research and healthcare actors in Luxembourg. Below a selection of some of our latest projects. 

Biomaterial collection for neurodegenerative disease research (ND collection)

To investigate the causes of neurodegenerative diseases, researchers need access to biomaterial and clinical data from patients and healthy controls to define disease markers and study mechanisms causing neuronal cell death. It takes substantial efforts to collect a large number of samples to be able to answer most urgent research questions. Here, anonymised participants’ clinical data and biosamples from this collection will help numerous research organisations in Luxembourg and abroad to advance the understanding and treatment of common neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases, epilepsy and inflammatory brain diseases. The IBBL (Integrated BioBank of Luxembourg) and the LCSB (Luxembourg Centre for Systems and Biomedicine) are co-sponsors of the Collection.

Advanced modelling of Parkinson’s disease with three-dimensional human midbrain organoids (3DPD)

The project aims to implement a novel 3D cell culture model to elucidate the effects of Parkinson’s disease on brain architecture and connectivity. The project is led by the Luxembourg Centre for Systems Biomedicine at the University of Luxembourg.

Standardisation of midbrain organoid generation and proof of concept for application (BrainOid)

The BrainOid project is a collaboration between IBBL, LIH, the University of Luxembourg and the FNR. It aims to generate prototype midbrain organoids from human stem cells that are ready for distribution and various applications. The first step will be to standardise their production and then to provide a proof-of-concept for toxicity and neurodegeneration testing. The midbrain organoids will be generated from human neuroepithelial stem cells (hNESC) derived from pluripotent stem cells (iPSC) originating from skin biopsies. Method validation will be conducted by IBBL. 

Exploring Mitochondrial Epigenetics as a cause of mitochondrial dysfunction in Parkinson's disease (EME)

Mitochondrial dysfunction is a prevalent actor in the pathology of Parkinson’s disease (PD). However, the underlying molecular mechanism of this mitochondrial dysfunction is not comprehended. The project aims to investigate a potential dysregulation of the mitochondrial DNA (mtDNA) epigenetics in platelets derived from PD patients. The project will assess the validity of mtDNA epigenetic profiles as a biomarker for early PD diagnosis and/or disease staging, as well as elucidate the causes of the detrimental mitochondrial defects in PD. This approach can help develop therapeutic strategies to prevent neuronal cell loss in PD. The study is a collaboration between the LCSB, the University of Luxembourg and IBBL.

Get Involved

Whether you have Parkinson’s disease or not, you can contribute to Parkinson’s research by participating in the National Centre of Excellence in Research on Parkinson’s Disease (NCER-PD), a collaboration between IBBL, the Luxembourg Centre for Systems Biomedicine (LCSB), the Luxembourg Institute of Health (LIH), the Centre Hospitalier de Luxembourg (CHL) and the Laboratoire National de Santé (LNS).

For more information on the NCER-PD programme and your participation, please visit www.parkinson.lu