General Population

Understanding why certain people develop a disease while others do not can help us find new ways of preventing the disease, detecting it as early as possible, and improve treatment options.

To discover what has changed inside the cells or tissues of a patient that has led to the development of treatments for cancer, diabetes or Parkinson’s, researchers need to have access not only to biological samples from patients, but also from people that do not have the studied disease, in order to draw comparisons. IBBL collects samples from healthy volunteers, called “control samples” for this use.

A resource for research

With the support of Dr Marc Keipes from the health centre Gesondheetszentrum at the ZithaKlinik, we currently collect blood and stool samples that are used as healthy controls for several of our disease-specific studies. So far we have over 80,000 samples in our storage facilities from participants recruited through the Gesondheetszentrum. This represents a large portion of our total sample collection, which is not surprising given that, for statistical purposes, researchers generally need 4 control samples for each diseases sample they use.

Keeping an eye on the population

Healthy volunteers can also participate in observational studies designed to collect nationally representative health data, helping public health authorities adopt prevention strategies and tackle the real needs of the population. Initially set up in 2007, with the support of the Luxembourg government, the ORISCAV study was developed to monitor the heart of 1,432 volunteers, aged 25-80 years. The outcomes raised striking alarms over the population’s cardio-vascular health. Researchers discovered that up to 80% of the population were afflicted by at least one cardio-vascular risk factor. The second wave of the study is currently ongoing. As the biobank of Luxembourg, we help the LIH – project coordinator, with the collection, processing and storage of the blood and urine samples collected.

Focusing in on diseases

We also recently started supporting a French epidemiological cohort, aiming to provide public health and epidemiological information to support research projects on a broad range of questions.

Our national projects 

IBBL is involved in a number of national projects on general population studies, in close collaboration with all major biomedical research and healthcare actors in Luxembourg. Below a selection of some of our latest projects.  

Normal POPulation sample collection project (POP)

The project aims to develop a collection of samples from the Luxembourg population to be used as ‘Control’ samples in scientific research projects. Specimens (known as “controls”) from healthy volunteers are indispensable for researchers to make comparisons in the laboratory between healthy and ill individuals. Participants are recruited prospectively from people undergoing occupational screening at the ZithaKlinik. IBBL is in charge of the processing and storage of samples. 

The second observational study of cardiovascular risk factors in the general population in Luxembourg (ORISCAV-LUX 2)

After the success of the ORISCAV-LUX study in 2008, the Luxembourg Institute of Health (LIH), supported by the Ministère de l’Enseignement Supérieur et de la Recherche (MESR), carried out a follow-up study, ORISCAV-LUX 2, which includes Luxembourg residents who already participated in the first cross-sectional survey. ORISCAV-LUX 2 is a follow-up to provide longitudinal data to monitor cardio-metabolic health and answer specific research questions. 

Get Involved

Biomedical research often involves the comparison of samples from patients to samples from healthy donors to gain more knowledge about the disease. This is why we collect samples from healthy volunteers that are used as “controls” in our disease-specific research programmes.

If you are healthy, you have several options to contribute to our research programmes:

  • Ÿ You can participate as a healthy control in the NCER Parkinson study
  • Ÿ You can donate a blood sample when you visit the ZithaGesondheetsZentrum at the ZithaKlinik, led by Dr Marc Keipes. These samples are used as healthy controls in cancer and biospecimen research projects.